Publikationen der Arbeitsgruppe

 

Photochemical ring expansion reactions: synthesis of tetrahydrofuran derivatives and mechanism studies

Sripati Jana, Zhen Yang, Chao Pei, Xinfang Xu, Rene M. Koenigs, Chem. Sci. 2019, manuscript accepted.

 

Artificial Intelligence-Driven Organic Synthesis – En Route Towards Autonomous Synthesis?

Claire Empel, Rene M. Koenigs, Angew. Chem. Int. Ed. 2019, DOI 10.1002/anie.201911062; Angew. Chem. 2019, DOI: 10.1002/ange.201911062.

 

Catalyst-Free [2,3]-Sigmatropic Rearrangement Reactions of Photochemically Generated Ammonium Ylides

Fang Li, Feifei He, Rene M. Koenigs, Synthesis, 2019, manuscript accepted.

 

Diazoacetonitrile (N2CHCN): a long forgotten but valuable reagent for organic synthesis

Pavel K. Mykhailiuk, Rene M. Koenigs, Chem. Eur. J. 2019, DOI: 10.1002/chem.201903335.

 

Visible Light Induced Metal-free Carbene N-Carbazolation

Claire Empel, Frederic W. Patureau, Rene M. Koenigs, J. Org. Chem., 2019, 84, 11316-11322.

 

Solvent-dependent, rhodium catalysed rearrangement reactions of sulfur ylides

Yang Zhen, Yujing Guo, Rene M. Koenigs, Chem. Commun., 2019, 55, 8410-8413.

 

Sustainable Carbene Transfer Reactions with Iron and Light

Claire Empel, Rene M. Koenigs, Synlett, 2019, DOI: 10.1055/s-0037-1611874.

 

Rhodium catalyzed carbene transfer reactions for sigmatropic rearrangement reactions of selenium ylides

Sripati Jana, Rene M. Koenigs, Org. Lett. 2019, 21, 3653-3657.

 

Visible light mediated, metal-free carbene transfer reactions of diazoalkanes with propargylic alchohols

Feifei He, Rene M. Koenigs, Chem. Commun. 2019, 55, 4881-4884.

 

Photochemical, metal‐free sigmatropic rearrangement reactions of sulfur ylides

Zhen Yang, Yujing Guo, Rene M. Koenigs, Chem. Eur. J. 2019, 25, 6703-6706.

 

Doyle Kirmse rearrangement reactions of difluoroacetates

Sripati Jana, Rene M. Koenigs, Asian J. Org. Chem. 2019, 8, 683-686.

This manuscript is part of a special issue on Organofluorine Chemistry.

Highlighted on chemistryviews.org.

 

Catalytic Synthesis of Trifluoromethyl Cyclopropenes and Oligocyclopropenes

Uyen P. N. Tran, Rene Hommelsheim, Zhen Yang, Katharina J. Hock, T. Vinh Nguyen, Rene M. Koenigs, ChemRxiv, chemrxiv.7545623.v1

 
indole Functionalization

Tryptamine synthesis by iron-heme catalyzed C—H functionalization of indole with diazoacetonitrile

Katharina J. Hock, Anja Knorrscheidt, Renè Hommelsheim, Junming Ho, Martin J. Weissenborn, Rene M. Koenigs, Angew. Chem., Int. Ed. 2019, 58, 3630-3634; Angew. Chem. 2019, 131, 3669-3673.

 

Difluorodiazoethane (CF2HCHN2): a new reagent for the introduction of the difluoromethyl group

Pavel Mykhailiuk, Rene M. Koenigs, Chem. Eur. J. 2019, 25, 6053-6063.

 
Carben Transfer with blue light

Blue Light Induced Carbene Transfer Reactions of Diazoalkanes

Rene Hommelsheim, Yujing Guo, Zhen Yang, Claire Empel, Rene M. Koenigs, Angew. Chem., Int. Ed. 2019, 58, 1203-1207; Angew. Chem. 2019, 131, 1216-1220.

 
dealkyltive intercepted rearrangements

Dealkylative intercepted rearrangement reactions of sulfur ylides

Claire Empel, Katharina J. Hock, Rene M. Koenigs, Chem. Commun. 2019, 55, 338-341.

 
 
tropylium

An efficient method for retro-Claisen-type C–C bond cleavage of diketones with tropylium catalyst

Mohanad A. Hussein, Vien T. Huynh, Rene Hommelsheim, Rene M. Koenigs, T. Vinh Nguyen, Chem. Commun. 2018, 54, 12970-12973.

 
XH Insertions

Iron-catalysed carbene-transfer reactions of diazo acetonitrile

Claire Empel, Katharina J. Hock, Rene M. Koenigs, Org. Biomol. Chem. 2018, 16, 7129-7133.

This article is part of the themed collection: Carbenes in Organic Synthesis

 
 
Cyanomethyl Anion Transfer

Cyanomethyl Anion Transfer Reagents for Diastereoselective Corey Chaykovsky Cyclopropanation Reactions

Rene Hommelsheim, Katharina J. Hock, Christian Schumacher, Mohanad A. Hussein, T. Vinh Nguyen, Rene M. Koenigs, Chem. Commun. 2018, 54, 11439-11442.

 
Indole Functionalization

Iron-Catalyzed C—H Insertions: Organometallic and Enzymatic Carbene Transfer Reactions

Katharina J. Hock, Anja Knorrscheidt, Renè Hommelsheim, Junming Ho, Martin J. Weissenborn, Rene M. Koenigs, ChemRxiv, 2018, DOI: 10.26434/chemrxiv.6011096.v1.

 
 

The Generation of Diazo Compounds in Continuous-Flow

Katharina J. Hock, Rene M. Koenigs, Chem. Eur. J. 2018,24, 10571-10583.

 
 
enantioselective sigmatropic rearrangements

Enantioselective [2,3]-sigmatropic rearrangement reactions - metal bound or free ylidesreaction mechanism

Katharina J. Hock, Rene M. Koenigs, Angew. Chem. Int. Ed. 2017,56, 13566-13568; Angew. Chem. 2017,129, 13752-13754.

 

Corey Chaykovsky Reactions of Sulfur Ylides Enable cis-Configured Trifluoromethyl Cyclopropanes

Katharina J. Hock, Renè Hommelsheim, Lucas Mertens, Junming Ho, T. Vinh Nguyen, Rene M. Koenigs, J. Org. Chem. 2017, 82, 8220-8227.

Enabling iron catalyzed Doyle-Kirmse rearrangement reactions with in situ generated diazo compounds

Katharina J. Hock, Lucas Mertens, Renè Hommelsheim, Robin Spitzner, Rene M. Koenigs, Chem. Commun. 2017, 53, 6577-6580.

Efficient Phosphine-Mediated C(sp3 )-C(sp3 ) Coupling Reactions of Alkyl Halides in Batch and Flow

Uyen P. N. Tran, Katharina J. Hock, Christopher P. Gordon, Rene M. Koenigs and T. Vinh Nguyen, Chem. Commun. 2017, 53, 4950-4953.

Towards nitrile-substituted cyclopropanes – safe and scalable applications of diazo acetonitrile

Katharina J. Hock, Robin Spitzner, Rene M. Koenigs, Green Chem. 2017 , 19, 2118-2122.

Difluoro- and trifluoro diazoalkanes – complementary approaches in batch and flow and their application in cycloaddition reactions

Katharina J. Hock, Lucas Mertens, Friederike K. Metze, Clemens Schmittmann, Rene M. Koenigs, Green Chem. 2017, 19, 905-909.

Rhodium catalyzed synthesis of difluoromethyl cyclopropanes

Katharina J. Hock, Lucas Mertens, Rene M. Koenigs, Chem. Commun. 2016, 52, 13783-13786.

Highlighted on chemistryviews.org.

Fluorinated diazoalkanes – a versatile class of reagents for the synthesis of fluorinated compounds

Lucas Mertens, Rene M. Koenigs, Org. Biomol. Chem. 2016, 14, 10547-10556.

Fluoroalkyl-substituted Diazomethanes and their Application in a General Synthesis of Pyrazoles and Pyrazolines

Lucas Mertens,# Katharina J. Hock,# Rene M. Koenigs, Chem. Eur. J. 2016, 22, 9542-9545 (# denotes equal contribution)